Driving Discovery

through Metabolic Systems Biology

Re-imagining the metabolic basis of cancer and identifying previously unrecognized liabilities for therapeutic intervention.

About the Patti Lab

The Patti Lab is a research team at Washington University in St. Louis dedicated to pioneering innovative metabolomics and isotope-tracer technologies to study biochemical processes across scales. In addition to a scientifically diverse group of staff scientists and postdocs, the team consists of PhD students from multiple different programs including biochemistry, cancer biology, chemistry, computational and systems biology, developmental biology, molecular cell biology, and molecular genetics and genomics.

Areas of Research

Our research has three complementary themes. Team members who focus on different areas work together closely, with advances in one often inspiring developments in another.

Join Our Team

The Patti Lab has positions available at all levels, including:

  • Postdoctoral Research Scholars
  • Graduate Students
  • Staff Scientists
  • Mass Spectrometry Technologist/Research Associates
  • Laboratory Managers
  • Post Doc in Cancer Metabolism
  • Agilent-Merck Postdoctoral Fellowship
  • Postdoctoral in Multi-Omics Research

Center of Mass Spectrometry and Metabolic Tracing

The Center of Mass Spectrometry and Metabolic Tracing combines a breadth of instrumentation with advanced in-house informatics platforms to accommodate a wide range of applications such as metabolomics, lipidomics, exposomics, and proteomics. Equipment is regularly refreshed to continuously push the limits of measurement science. Technologies currently available include: GC/MS and LC/MS workflows; EI, ESI, DESI, and MALDI sources; time-of-flight and Orbitrap analyzers; trapped ion mobility spectrometry and traveling wave ion mobility spectroscopy; NMR spectrometers; and high-resolution respirometers.

NIH Center for Multi-Omics Production

The Patti Lab is proud to be recognized by the NIH Multi-Omics of Health and Disease Consortium. Partnering with the Wang Lab, we created the Washington University Omics Production Center to acquire whole genome sequencing, whole genome bisulfite sequencing, ATAC-seq, RNA-seq, proteomics, metabolomics, lipidomics, and exposomics data from the same set of disease samples provided by NIH Disease Study Sites.


  • Metabolite study and structural authentication for the first-in-human use sphingosine-1-phosphate receptor 1 radiotracer

    View Summary
  • HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species

    View Summary
  • Cardiometabolic Characteristics of People with Metabolically Healthy and Unhealthy Obesity

    View Summary