How to target tumours by messing with their metabolism

IN 1924, German biochemist Otto Warburg observed that cancer cells are extraordinarily greedy. Tumours tend to grow rapidly, so it made sense that they had outsized appetites. But Warburg also found that the way they burned, or metabolised, the resources they gobbled so hungrily was different. He was convinced that this change in metabolism defined cancer – and figuring out what drove it would let us beat the disease.